Rana Alaa El-Din Youssef ¹, Nadia Mostafa Lotfy ², Nagla Mahmoud Salama ³, and Ahmed Ali Elsayed ^{4         1. Teaching assistant, Department of Oral pathology, Faculty of Dentistry, Mansoura University. 2. Professor of Oral Pathology, Faculty of Dentistry, Mansoura University. 3. Assistant Professor of Oral Pathology, Faculty of Dentistry, Mansoura University. 4. Lecturer of pathology, Faculty of Medicine, Mansoura University.} Abstract:    Background: Glut-1 is a glucose transporter protein with high affinity and clear potential to provide cellular growth advantages. It is overexpressed in many tumors. Aim of the study:The objectives of the present study were to compare Glut-1 expression in dysplastic and OSCC cases as a suggested model of multistage carcinogenesis Materials and methods: Thirty cases of OSCC, including 16 cases with epithelial dysplasia, were graded histopathologically. Immunohistochemical method was used to detect the expression of Glut-1 in dysplastic epithelium and OSCC. The scores were compared using the chi-square test Results: Statistical analysis demonstrated positive correlation between Glut-1 expression and histopathological grades of OSCC and different grades of epithelial dysplasia Conclusion: It can be concluded that Glut-1 has a consistent role in oral carcinogenesis, and it can be used as a reliable prognostic marker for the evaluation of oral epithelial dysplasia (OED) and OSCC.