Angiogenesis is essential for the growth, invasion and metastasis of solid tumors. CD105 has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. The present study was carried out to investigate the immunohistochemical expression of CD105 in OSCC and correlate its expression in different histological grades as well as the available clinical parameters. Retrieved paraffin blocks of 30OSCC cases were used to evaluate CD105 immunohistochemical expression. Analysis revealed a statistically significant difference in CD105 expression among the different histologic grades and clinical stages.