Introduction:Chronic periodontitis is a common public health concern characterized by a progressive gingival inflammation. Objective:The aim of this study was to assess the clinical and laboratory effect of diacerein as an adjunctive therapeutic management to conventional periodontal therapy (SRP) of moderate chronic periodontitis. Subjects and Methods: Thirty patients (n=30) suffering from moderate chronic periodontitis were involved based on specific criteria. These were divided into control and study group and subjected to SRP. The study group was administered diacerein in the form of a gel-formula into the periodontal pocket using the local delivery system. Clinical parameters were collected and compared between and after treatment any analysed by descriptive and non-descriptive statistical analysis using the Chi-square test. Results:  Our analysis showed that age and gender was not found significantly different between the two studied groups. However, there was a statistically significant higher median values of clinical indices after treatment among control than study group as well as significant decrease of median values of clinical indices after treatment as compared to pre-treatment results among the study group (p < 0.05). Interestingly, a significant decrease of mean IL-β1 after treatment among both groups with more significant decrease among the study group comparing to control group (p < 0.05). Conclusion: Diacerein can provide alternative and promising therapeutic option as well as safe, and effective drug particularly along the non-surgical SRP procedure for the management and control of chronic periodontitis.