Background:Patients with choric periodontal diseases have high levels of lactate dehaydrogenase(LDH) in gingival cervical fluid  (GCF) . Garcinia mangostana (MGA), more popularly known as mangosteen   can be used as an adjunct to SRP to provide a new dimension to periodontal therapy . Aim: To evaluate the effect of garcinia mangostana extract gel as a local drug delivery in treatment of chronic periodontitis patients. Assessment of Lactate dehydrogenase enzyme levels in GCF of such patients.   Subjects and methods:  Ten patients (MGA group) were treated with SRP, and the subgingival application of mangostana gel was used as local drug delivery. Ten patients (chlorhexidine gel) were treated with SRP and chlorhexidine gel. Ten patient treated with SRP only . Five group (control group).Clinical parameters were recorded  and at the one month and samples of GCF  were analyzed using  ldh ELISA kit for all group. Results:All periodontal parameters(PI,BOP,PPD,CAL) and Laboratory analysis results LDH were reduced significantly by local drug delivery    treatment. Conclusion:Scaling and root planning (SRP) is an effective treatment  in chronic periodontitis patients associated with local drug deliveryرررررر therapy (mangostana gel) can improve the GCF level of one of the inflammatory biomarkers (LDH)  .ر