This paper presents a correlation between the panoramic indices measured on the mandible and osteocalcin serum level. A forty-fivefemale patients were involved in the study. Group 1 (case group): 15 female postmenopausal osteoporotic patients. Group 2 (control group): 30 female patients who were never known to be osteoporotic and was sub-grouped into Subgroup 2A: 15 female patients who were in premenopausal stage and Subgroup 2B:15 female patients who were in the postmenopausal stage.DEXAscan was done for all patients to assess bone density. Panoramicviews were made for all patients for different dental treatment aims. Informed consent was taken from all patients. A blood sample was collected from each patient after instructing them to fast for 12 hours prior to admission to our dental clinic at faculty of dentistry as outpatients. Osteocalcin levels were measured by liquid chromatography– tandem mass spectrometry ⁽¹⁾The correlation between panoramic indices and osteocalcin serum level was determined.The resultsshows a significant positive correlation between the gonial index (GI) on the left side of the mandible and serum osteocalcin level in the study group (p=0.04). There was a significant positive correlation between Antegonial index (AGI) on the left side of the mandible and serum Osteocalcin level in control 2A group (p=0.09). There was no significant correlation between any of the panoramic mandibular measurements and serum Osteocalcin level in control 2B group.