Lina Mohamed Elmasry, ¹ Mohamed ZaghloolAmer,²Eman Abdel Salam Yousef ^{3 1} College Of Master Degree In Oral & Maxillofacial Surgery- Faculty of Dentistry- Mansoura University ² Professor of Oral & Maxillofacial Surgery Faculty of Dentistry- Mansoura University ³ Lecturer of Oral & Maxillofacial Surgery Faculty of Dentistry- Mansoura University Abstract: Problem Statment Nowadays using mini implant in replacement single tooth is considered as a major challenge in dentistry especially, with limited quality bone type and immediate loading pattern. This study was directed to evaluate osseointegration of mini implants with two different loading protocols; early and immediate occlusal loading of single tooth replacement in the maxillary anterior region. Patients and Methods Sixteen patients seeking for replacement of single missing tooth in the maxillary esthetic zone with mini implant were included in two harmoniously distributed groups. In the 1^st group, eight patients received mini implants with immediate loading protocol within 72 hrs from surgery. While in the 2^nd group, eight patients received mini implanst with early loading protocol within 6 weeks from surgery. All patients included in this study were evaluated clinically either immediately (T0), 6 (T1), 12 months (T2) post-operatively regarding to implant stability, angulated bleeding index, modified plaque index andmarginal bone level by intraoral peri-apical radiographs and pink esthetic zone. Results No statistical significant differences were found among both groups between values recorded at successive periods of assessment either at (T0) or (T1) and (T2) regarding to modified sulcus bleeding index (P= 0.480, 1.000, 0.725 respectively)and implant stability(P= 0.680, 0.725, 0.687 respectively)and marginal bone level (P=0.370, 0.149 respectively). Significant differences were recorded within each group when comparing T0 values versus those values declared at T1 and T2  with regard to implant stability (p-0.008, 0.007) and MBL (P= <0.001, <0.001) respectively. Conclusion  Mini implant can be considered as a suitable treatment modality for replacement of an anterior missing tooth of limited space with lack of significant insult of different loading protocols on its success.