Rami M. Galal^{1, 2, 3}, Salah A Youssef ⁴  andHaidy N. Salem^{5 1} Researcher, Fixed and removable prosthodontics department, Orodental division, National Research Centre ² Lecturer, Fixed Prosthodontics Department, Faculty of Oral and Dental Medicine, Al Nahda University (NUB) ³Lecturer, Fixed Prosthodontics Department, Faculty of Oral and Dental medicine, Al Ahram Canadian University (ACU) ⁴Lecturer of Crown and Bridge Department. Faculty of Dental Medicine.Al-Azhar University.Assiut branch. ⁵Lecturer. Restorative and dental materials research department, National Research Centre Abstract: Aim of the study:The aim of this study is to assess the efficacy of Panavia luting agent bonding with three all ceramic systems (CEREC, VITA VM7 and E-max) treated with three surface treatments (alumina abrasion, hydrofluoric acid and combination of the two methods) . Materials and methods:Ninety mandibular teeth were used. They were divided into three groups regarding the method of treatment (alumina abrasion, hydrofluoric acid and combination of the two methods).  Then the groups were subdivided into: ceramic system subgroups (CEREC, E- max and VITA VM7).Compressive load was applied on the cementation interface and shear bond was assessed. Statistical analysis was done using two ways analysis of variance (ANOVA) and Tukey's Post – hoc test. Results : The highest shear bond strength was with cementing of CEREC ceramic system with the Panavia cement after hydrofluoric acid surface treatment(10.9 Mpa).But the least was with cementing the VM7 after alumina abrasion (4.9 Mpa). Conclusion:The surface treatment to the different ceramic systems showed the highest bond strength with Panavia cementation was the hydrofluoric acid etching.