Karim H. Abd-El Maksoud¹, Hamdi H. Hamama ², Nadia M. Zaghloul^{3 1} Demonstrator, Department of Operative Dentistry, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, ² Lecturer of Operative Dentistry, Faculty of Dentistry, Mansoura University, ³ Associate Professor of Operative Dentistry, Faculty of Dentistry, Mansoura University. Abstract: Objectives: management of deep dentine carious lesion usually carry a great risk of pulp exposure and Silver Diamine Flouride is a recent therapeutic and prophylactic agent for management of deep dentine carious lesion with minimal surgical intervention. : The aim of this study is to investigate the effect of silver di amine flouride/potassium iodide (SDF) on the micro shear bond strenght of resin modified glass ionomer to dentine of permenanet molar. Methods: One hundered and twelve permenant third molars were randomly assigned to control group (N=56 sound third molars) and experimental group (N=56 third molar with moderate caries frank 5 according to ICDAS). Each group was divided into two sub- groups according to conditioning method (N=28 etching with phosphoric acid 37%) (N=28 etching with poly acrylic acid 25-30%). Each sub group is divided into two divisions according to application of SDF (N=14 with application of silver di amine flouride) (N=14 withoud silver di amine fluoride. Each division is divided into two sub-divisions according to storage time ( N= 7 stored for 6 months) ( N=7 stored for 24 hours) Results: there was a significant difference in the microshear bond strength regarding to the groups of dentine pretreatment with SDF/KI and stored for 6 months as they have the lowest microshear bond strength values. Conclusion:Dentine pretreatment with Silver Diamine fluoride/ Potassium Iodide decrease Microshear bond strength with RMGIC