Sofia Sidahmed, Laila Gadalla, Samah H. Elmeadawy,  faridbadria* *Oral Medicine and Periodontology Departments, Faculty of Dentistry and Faculty of Pharmacy, Mansoura University Abstract: Objective:The objective of this study is to evaluate the efficacy of aloe vera gel in the treatment of oral lichen planus (OLP) compared with placebo. Subjects and Methods:Twenty-one females suffering from the clinical signs and symptoms of OLP were grouped into: I. Patients' group receiving AV geldivided in two subgroups: Group (A): they received AV 70%concentration Include seven patients. Group )B): they received AV 90%concentration Include seven patients. II. The second (control) group received placebo Include seven patients. Result:There was no statistically significant difference between ulcer size at all points of follow up in Egyptian and Australian AV compared to placebo. Erythema score among study groups at different times the erythema score decreased in both types of AV. There was no statistically significant difference between erythema at 2 and 4 weeks of follow up in Egyptian (group I/A) and Australian AV (group I/B) compared to placebo. However, statistically significant difference was found between Australian AV and placebo treatment at final visit (p < 0.05). The mean reticulations decreased in both Egyptian and Australian groups at 2, 4, 6, 8 weeks with statistically significant difference was found between for Egyptian & Australian AV compared to placebo treatment at 4, 6 weeks visits (p < 0.05). The mean total area of lesion decreased in both Egyptian and Australian groups at 2, 4, 6, 8 weeks with statistically significant difference was found between for Egyptian AV compared to placebo treatment at 6 & 8 weeks visits (p < 0.05). Pain score evaluation decreased in both Egyptian at the 6^th week and Australian groups at 4,6,8 weeks with statistically significant difference (p < 0.05). The degree of change was higher in Egyptian than Australian AV regarding size, erythema, reticulation and total area of lesion. However, there was no statistically significant difference between two types of treatment as regards all measured parameters (p>0.05). Conclusions: AV gel whether Egyptian or Australian is statistically significantly more effective than placebo in inducing marked improvement clinically of OLP. Therefore, AV gel can be considered a safe alternative treatment for patients with OLP.