Objectives: The aim of the present studyis to evaluate the effect of hyaluronic acid (HA) in combination with Beta-tri-calcium phosphate (𝛽TCP) in treatment of vertical bone loss in periodontitis patients clinically and radiographically.
Patients and methods: Forty patients diagnosed as stage III & grade B periodontitis with vertical bony defects and showed radiographic bone loss ≥5mm were selected from periodontology and oral medicine department faculty of dentistry Mansoura University. The patients were divided into four groups. Group I treated with combination of hyaluronic acid (HA) and Beta-tri-calcium phosphate (𝛽TCP). Group II treated with HA alone, group III treated with 𝛽TCP alone and group IV treated by open flap debridement using minimally invasive surgical technique. Clinical periodontal parameters (plaque index PI, gingival index GI, clinical probing depth PD, clinical attachment level CAL) were taken from each patients at baseline , 3 months and 6 months after treatment. Periapical radiographs were taken for each patient to evaluate the radiographic bone level change before and after treatment. The radiographs were taken at baseline, 3 months and 6 months from surgery.
Results: Clinical periodontal parameters were significantly improved after treatment in all treatment groups compared to the baseline. There was a statistically significant difference among the treatment groups between the base line, after 3 months and after 6 months from surgery (p value ≤0.05). Regarding bone level there was gain in the bone level after treatment in all treatment groups with significant improvement in group I (HA+ 𝛽TCP). There was a statistically significant difference among the treatment groups between the base line, after 3 months and after 6 months from surgery (p value ≤0.05).
Conclusions: Combination of Hyaluronic acid and (𝛽TCP) gave good results in the treatment outcomes as regard bone level and periodontal clinical parameters. Hyaluronic acid in combination with (𝛽TCP) showed a synergistic effect on regeneration of vertical bony defects.