PURPOSE. This study aimed to evaluate the bond strength of two resin cements to lithium disilicate ceramic after different etching and priming protocols. MATERIALS AND METHODS. 64 lithium disilicate discs (IPS e.max press) were fabricated by pressing technique then divided into two groups (n=32) group (I) multi-step adhesive resin cement (Multilink® N); group (II) self-adhesive resin cement (Maxcem Elite®). Each group was subdivided into four subgroups (n=8) according to surface treatment material; (A): Monobond Etch & Prime, (B): Hydrofluoric acid, (C): Acidulated phosphate fluoride (D): Ammonium hydrogen difluoride. Composite resin discs (Nexcomp®) were cemented to treated ceramic discs. All bonded specimens stored in water bath for 5 months and subjected to 5000 thermal cycles. Shear bond strength (SBS) test was performed using a universal testing machine. Scanning Electron Microscope (SEM) was used for specimens' examination. RESULTS. Statistical analysis were done using two-way ANOVA and serial one-way ANOVAs followed by Post Hoc Tukey-HSD test at α =0.05. The highest SBS mean value 17.05±3.99 MPa, 16.59±2.27 MPa was obtained for APF and HF at multi-step adhesive cement. On the other hand, AHDF with self-adhesive resin cement showed the lowest SBS mean value 6.71±1.46 MPa. There was statistically significant difference between AHDF and other used materials. CONCLUSION. Multi-step adhesive resin cement showed superior bond strength than self-adhesive resin cement. Also, HF acid and APF were preferred to be used more than Monobond Etch & Prime for ceramic surface treatment as they significantly affected the durability & bond strength regardless used cement type.