Aim: The aim of this study was to determine the effect of scaling and root planing  onceruloplasmin  level  in  chronic  periodontitis  patients. Materials and Methods:Forty participants were involved in this study. Twenty patients with moderate to severe chronic  as study group and other twenty healthy  subjects were enrolled in the study to a control group. Study group was further subdivided into two subgroups (ten patients for each) sever chronic periodontitis ( group IA) and moderate chronic periodontitis (group IB. Clinical periodontal parameters (Periodontal pocket depth, Clinical attachment loss and Bleeding on probing) were recorded at baseline for two groups (study and control group).  Serum samples were be taken two times from each patient in the study group, the 1st serum sample will be taken at the first appointment  before starting the treatments which is scaling and root planing for each  patient. The patient will be treated twice a week for three weeks. After 4 weeks of treatment the 2nd  serum  samples  were  be taken. However in control group serum sample was taken only once. The blood samples will be analyzed using Ceruloplasmin Assay Kit. Results:Serum ceuloplasmin level showed  asiginificant difference between chronic periodontal patient (study group)  and healthy subjects  (control group) at baseline (p < 0.001).   Concerning the study group, four  weeks after SRP, the mean values of serum ceruloplasmin concentration was decreased (P < 0. 001). However, there was no statistically significant differences between the mean value of serum ceruloplasmin  of the study group after treatment and control group at P= 0.209. Conclusions:Serum ceruloplasmin level represent an a potential biomarker indicator of the chronic periodontitis disease. Serum ceruloplasminlevel have an relationship with severity of chronic periodontitis. SRP have a suppressive (reducing) effect on the serum ceruloplasmin level in both moderate and severe chronic periodontitis patients. Aim: The aim of this study was to determine the effect of scaling and root planing  onceruloplasmin  level  in  chronic  periodontitis  patients. Materials and Methods:Forty participants were involved in this study. Twenty patients with moderate to severe chronic  as study group and other twenty healthy  subjects were enrolled in the study to a control group. Study group was further subdivided into two subgroups (ten patients for each) sever chronic periodontitis ( group IA) and moderate chronic periodontitis (group IB. Clinical periodontal parameters (Periodontal pocket depth, Clinical attachment loss and Bleeding on probing) were recorded at baseline for two groups (study and control group).  Serum samples were be taken two times from each patient in the study group, the 1st serum sample will be taken at the first appointment  before starting the treatments which is scaling and root planing for each  patient. The patient will be treated twice a week for three weeks. After 4 weeks of treatment the 2nd  serum  samples  were  be taken. However in control group serum sample was taken only once. The blood samples will be analyzed using Ceruloplasmin Assay Kit. Results:Serum ceuloplasmin level showed  asiginificant difference between chronic periodontal patient (study group)  and healthy subjects  (control group) at baseline (p < 0.001).   Concerning the study group, four  weeks after SRP, the mean values of serum ceruloplasmin concentration was decreased (P < 0. 001). However, there was no statistically significant differences between the mean value of serum ceruloplasmin  of the study group after treatment and control group at P= 0.209. Conclusions:Serum ceruloplasmin level represent an a potential biomarker indicator of the chronic periodontitis disease. Serum ceruloplasminlevel have an relationship with severity of chronic periodontitis. SRP have a suppressive (reducing) effect on the serum ceruloplasmin level in both moderate and severe chronic periodontitis patients.