Background:Propolis has many advantages but the healing of buccal mucosal wounds is one of his challenges. Propolis has many properties but the most important is antimicrobial activity, especially against bacteria, and high success rate in many clinical uses.
Aim of the study: To evaluate the effect of topical application of propolis on mucosal wound healing.
Materials and Methods:40 male albino rats were used. The animals were classified into four main groups, ten rats for each group: Group I, II  were subjected to surgical wound in the buccal mucosal area without using any treatment materials for 4 and 7 days respectively. Group III, IV  were subjected to surgical wound in the buccal mucosal area with propolis treatment for 4 and 7 days. The rats were sacrificed after the specific duration. Section were prepared for staining by Haematoxylin-eosin(H-E) and trichrome stain.
Results:results  showed  more epithelization, collagen fiber formation in experimental groups than control groups.
Conclusions:The histological examination revealed enhanced buccal mucosal wound healing by using propolis.