Objective: The prevalence of oral cancer among population resident in East of Delta of Egypt, and the possible associated risk factors of oral cancer Materials and Methods:A total of (368)  patients  of both sexes, aged (13-83) years, were found suffering from benign and malignant oral cancer that was diagnosed and managed by oncology center - Mansoura University (2010-2013),using  IbnSina System of Oncology center. Results:A total of 368 patients were suffering from oral tumors, 53 cases died so the study included 315 patients, classified into age groups (Adolescents 13-19 yrs. young adults 20-40 yrs. Adulthood 41-64yrs. Old age 65 and more). With a mean of 51.8 ±17.2 years . The results showed that oral cancer was more prevalent at Adulthood groups. Malignant cases had higher mean age (55.48 ±15.18) compared to benign cases (42.43±18.54). Males were more liable to oral cancer than females. Most of cases were from Dakahlia governorate 219 patients (69,52%). The highest percentage of cases (27.72%) was found in year 2012, while the least percentage of cases (20.92%) was recorded in year 2011.The highest percentage was forfondle home cases (32.70%). Malignant tumors were highest among farmers 83.33% while they were least among students 29.17%. Tongue and lip were most common sites of oral cancer while the floor of the mouth and parotid gland were the least sites. Squamous cell carcinoma was the most common tumors followed by Basal cell carcinoma.Diabeteswas the highest systemic disease while hepatitis was the lowest. Vegetables were consumed by majority of cases (87.3%), with (44.13%) and (86.35%) of cases reported eating fast foods and fruits respectively.Starchyfoodswere the highest (95.24%) consumed food while milk was the least (38.10%). Conclusions:The cause of oral cancer is basically unknown even if some etiological predisposing factors have been found. This study partially confirms results of other oral cancer studies. Incidence may increase due to early diagnosis and therefor the morbidity will also increase.