The objective of this study was to study the effect of curcumin (CUR) on rats with chronic kidney disease. Forty-two male albino rats weighing 160 ± 5 g have been used in this study. The first group (n = 6) was fed on a basal diet (control -ve). To induce CKD in rats, adenine was added to the diet by about 0.75% w/w "adenine diet". Rats in this study (n = 42) were divided into 7 groups (n=7 rats) and fed on a tested diet for 6 weeks: group1 : fed on a normal diet, and used as a normal control group, group2 : fed on adenine diet, and was used as a CKD control group, group 3 : fed on low protein diet "12.5% protein" containing 0.75% adenine "low protein adenine diet", group 4 & 5: fed on adenine diet containing 100 and 150 mg curcumin/kg diet, respectively, group 6 & 7 : fed on low protein adenine diet containing 100 and 150 mg curcumin/kg diet, respectively. Results have shown that all chronic kidney disease groups receiving 100 mg and 150 mg curcumin have produced varying increases in body weight gain, feed intake, and feed efficiency ratio. The results showed that there was a significant decrease (P ≤ 0.05) between the groups which were treated with an adenine diet or low protein adenine diet containing 100 mg and 150 mg curcumin in internal organ weights, as compared to the positive control group. Liver enzymes including (aspatate amino transferes (AST), alannine amino transferes (ALT), and alkaline phosphatase  (ALP)), kidney functions (uric acid, urea nitrogen, and creatinine), lipid profile (cholesterol, triglycerides, LDL-c, VLDL-c), and malondialdehyde increased significantly in the positive control group, while HDL-c and the glutathione decreased significantly, as compared to the negative control group. All treated groups with adenine diet or low protein adenine diet containing 100 & 150 mg curcumin/kg diet showed significant decrease in these parameters except HDL, as compared to the positive control group. So, this study recommended using curcumin for kidney diseases.