The aim of this study was to investigate the effects of sage, sesame and olive oils alone and in combination with sage on total lipid (TL), total cholesterol (TC), triglyceride (TG), serum lipoprotein fractions (HDL-c, LDL-c and VLDL-c), liver enzymes and antioxidant enzymes, as well as histological changes of liver in obese nonalcoholic fatty liver disease (NAFLD) albino rats.    A total of 72 adult male albino rats weighing (200 ± 10g) were used in this study. The rats were divided into two main groups: The first group (8 rats) fed on basal diet (BD) as control negative group (-ve). The second main group (64 rats) fed on high fat diet (HFD) for (8) weeks to induce non-alcoholic fatty liver disease (NLFLD). then rats were divided into (8 subgroups). One (8 rats) fed (HFD), as positive control group (+ve). The other (7 subgroups) fed on modified (HFD), one of them by adding 5% sage. The other sex subgroups were fed on modified high fat diet (MHFD) by replace 20% sheep tallow (ST) by 20% sesame oil (SO), 20% olive oil (OO) and mixed 10% (SO) with 10% (OO) without or with sage for (8 weeks). Results revealed that, (MHFD) by adding 5% sage or by replacing 20% (ST) to 20% from (SO), (OO) and 20% mixed between them (1:1 W/W) without or with 5% sage induced a significant decrease in serum liver enzymes (Aspartate AminotransferaseAST, Alanin Aminotransferase ALT, and Alkaline phosphates ALP), total cholesterol, triglyceride, LDL-c and VLDL-c, while results revealed a significant increase in HDL-c level. Also results revealed a statistical significant increase in antioxidant enzymes glutathione peroxidase, superoxide dismutase and catalase antioxidants, as compared to the (+ve) control group. Histopathological examination revealed that only (NAFLD) group fed on (MHFD) containing 20% mixed (SO) with (OO) (1:1 W/W) plus 5% sage showed the best ameliorates of fatty liver. In conclusion, replacing 20% from (ST) by 20% from mixed (SO) with (OO) (1:1 W/W) plus 5% sage, ranged somewhere between them rise the effects of either component alone and induced the greatest improvement in case of (NAFLD) fed on (HFD).