The aim of this study was to investigate the effects of sage, sesame and olive oils alone and in combination with sage on daily feed intake (FI), body weight gain% (BWG%), organs weight to body weight ratio, peritoneal fat pad ratio, serum blood glucose and leptin hormone in nonalcoholic fatty liver disease (NLFLD). A total of 72 adult male albino rats of Spragu-Dawley Strain weighing 200 ± 10g were used in this study. The rats were divided into two main groups. The first group (8 rats) was fed on basal diet (BD) and used as a control negative group (-ve). The second main group (64 rats) was fed on high fat diet (HFD) for (8) weeks to induce non-alcoholic fatty liver disease (NLFLD). NLFLD rats were divided into (8 subgroups). One of them (8 rats) was fed on (HFD), used as a positive control group (+ve). The other (7 subgroups) fed on modified (HFD), one of them by adding 5% sage. The other subgroups were fed on modified (HFD) by replace 20% sheep tallow (ST) to 20% sesame oil (SO), 20% olive oil (OO) and mixed 10% (SO) with 10% (OO) without or with sage for (8 weeks). At the end of experiment, rats were anesthetized by ether before sacrificing after fasting overnight, liver, kidney and peritoneal fat pad were then taken and weighted. Blood samples were collected, left to clot, the serum was separated, glucose and leptin level were determined. The obtained results revealed that, feeding obese (NLFLD) rats on modified high fat diet (MHFD) containing 5% sage or by replacing 20% (ST) to 20% (OO), 20% (SO) or mixed 10% (SO) with 10% (OO) plus or without 5% sage significantly decreased body weight gain%, relative weight of liver, kidney and peritoneal fat pad%, serum fasting blood glucose and leptin hormone. Our results revealed that, mixed 10% (SO) with 10% (OO) plus 5% sage may represent a potentially therapeutic provide the greatest activity decrease in BWG%, organs weight / body weight %, peritoneal fat pad%, fasting blood glucose and leptin hormone level of obese nonalcoholic fatty liver disease (NLFLD) in rats.