Azathioprine (AZA) is a type of immunosuppressant medicine used in organ transplantation and autoimmune conditions.  Therefore, this study aimed to evaluate the role of dried kiwi fruit, kiwi fruit peels and kumquat fruits against liver toxicity induced by azathioprine in male albino rats.Forty- eight male Sprague Dawley rats were divided into two main groups. The group I was served as normal control. Group II was daily received 10 mg/kg from azathioprine dissolved in saline and gave by gavage for 7 days to induce hepatotoxicity. After that, the second group was divided into equal 7 subgroups. One of these groups kept as (+ve) control group and received basal diet only, at the same time, the experimental fruits were given in the form of powder mixed with the basal diet (kiwi fruit, 5%&10%, kiwi fruit peels 2.5% &5% and kumquat 5%&10%) respectively .At the end of the experiment (4 weeks), the rats were scarified, the serum was analyzed for(AST ),(ALT),(ALP) levels, Gamma-glutamyl transferase (GGT), uric acid and creatinine .Also  liver tissues were analyzed for superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), as well as histological examination was done  Furthermore, feed intake (FI), body weight gain (BWG%), feed efficiency ratio (FER) and relative weight of liver calculated. Moreover , the proximate composition of fruits were determined. Results elucidated that the tested fruits caused an increase in SOD, CAT and decreased the elevation of AST, ALT, ALP, GGT, uric acid,  creatinine, in serum and MDA in liver tissue compared to AZA group.The tested fruits can be served as potent curative agents against the liver toxicity .After testing it on some volunteerswhich, may be due toits anti-oxidant and anti-inflammatory activities.