The present study was carried out to investigate the effects of supplemented high fat diet (HFD) with two levels (1.5 and 3%) from dried unripe or ripe sour orange peel on serum leptin, glucose, lipid profile and liver functionsof albino rats. A total of 36 male albino rats weighing (40±5g) were used.The rats were divided into two main groups.The first main group (n=6) fed on basal diet (BD) and used as a negative control group (-ve). The second main group 30 rats fed on high fat diet (HFD) and divided into five subgroup. The first subgroup fed on (HFD) all over the experimental period and used as a positive control group (+ve). The other (4subgroups) were fed or (HFD) supplemented with two levels (1.5 or 3%) from dried unripe sour orange peel (DURSOP) or dried ripe sour orange peel (DRSOP) for 8 weeks. At the end of experiment, rats were sacrificed and blood samples were collected, then serum was separated, glucose, leptinlevel, lipid profile as well as AST, ALT and ALP enzymes were determined. The obtained results revealed that feeding 25 days of age albino rats on (HFD) supplemented with (3% from DURSOP or DRSOP) induced a significantdecrease in serum leptin, glucose, total cholesterol (TC), triglycerides (TG), LDL-c, VLDL-c, AST, ALT and ALP, on the other hand significant increase in serum HDL-coccurredin albino rats fed on HFD supplemented with (3%) from (DURSOP) or (DRSOP) followed by group fed on (HFD) supplemented with (1.5%). In conclusion,the results showed that administration of citrus unripe or ripe sour orange peel at levels (3 or 1.5 %) to rats fed on (HFD) could assist in management of obesity and its complications.