This study was performed to investigate the effects of diet containing fortified bread with 10% flax seeds (FS), grape seeds (GS) and their combination on rats suffering from acute liver disease.Different levels of diet containing fortified bread with(5 , 10, and 20%) flax seeds, grape seeds and their combination were used in preparing of tested breads which were subjected to sensory evaluation.The best level of fortified breadaftersensory evaluation was 10%. Chemical analysis of this level (10% )|was determinedand used in the biological experiment .Twenty-five male albino rats were randomly divided  into two main groups, the first main group (n=5 rats) fed on basal dietcontaining un-fortified bread and kept as a control negative group. The second main group(n=20rats) were injected with single dose of carbon tetrachloride(CCL₄) in paraffin oil 50% V/V(4ml/kg b.wt) subcutaneous injection to induce acute damage of  the liver, after that the injected group was divided into 4 subgroups as the following , subgroup 1 fed on basal diet containing un-fortified bread as positive control group, subgroups 2 ,3 and 4 fed on diet containing fortified bread with(10% flax seeds),(10% grape seeds) and (10% mix of them), respectively.The obtained results revealed that the injected groups with 10% FS or GS or mixture of them (FS& GS) had significant decrease in serum levels of total cholesterol , triglycerides , LDL-c , VLDL-c , blood urea nitrogen , uric acid , creatinine , aspartate aminotransferase (AST) , alanine aminotransferase (ALT) , Glucose , alkaline phosphatase (ALP) enzymes and organs weight/ body weight% but body weight gain% and serum levels of HDL-cwere increased significantly,when compared with those of positive control group, butnon significant in feed intake which nearly returned toward the positive control group.Partially improvements in liver structures and kidney compared to those of positive control group.The best improvements of all the biochemical parameters and histological structures of liver and kidney which were tended toward normal results were observed in  group was treated with mixture of 10%(FS&GS).In conclusion,the present findings suggested that regular intake from mixture of 10%(FS&GS) may be useful in improving liver and kidney functions and may protect against(CCL₄) which induce acute damage of the liver in rats.