Ginger and curcuma a widely used fruit in many countries for its nutritional benefits.  The main target of this study was to investigate the effect of two different concentrations (2.5% & 5%) of Ginger and curcum powderon fatty liver (FL) of male albino rats. The experiment was carried out using forty-two male albino rats. These rats were fed on basal diet for one week before then divided into six main groups (seven rats of each). Group 1: Negative control group fed on basal diet. Group 2: Positive control group will be fed on basal diet + Oxytetracycline injection (120 mg / kg / body weight per day), that after 28 days. ‘Rats will be injected intraperitonealy with Oxytetracycline for three consecutive days to induce fatty liver induction . Group 3 and Group 4: As the same of group 2 with 2.5 % and 5 % Ginger powder respectively. Group 5 and Group 6 : As the same of group 2 with 2.5 %  and 5 % Curcum powder respectively. At the end of the experimental period rats were fasted overnight and sacrificed; blood samples were collected from the aorta to determine lipids profiles. Besides, biological parameters were recorded. From the obtained results we concluded that feeding  rats which were suffering from FL with ginger and curcum powder at 2.5% & 5% improved the body weight. Our results could be summarized that diet fortified with 2.5% and 5% ginger and curcum powder helped to improve blood lipid levels, liver and kidney function compared with the positive control group (injected with oxytetracycline) which were considered as a major risk factor for fatty liver disease.