This study was conducted to investigate the effect of some medicinal plants against cisplatin induced infertility in experimental male rats. Thirty mature albino rats weighing 180-220g. Rats used in this study  divided into 6 equal groups, one was kept as a control –ve group, while the other 5 groups were injected intraperitoneally( IP) with a single dose of  cisplatin (CP) (7ml / kg B.Wt.). After induction, one group was kept as (+ve) control group, while others  given administration of  medicinal plants [ethanolic extract of  Psidium guajava leaves (EEPGL) and ethanolic extract of  Moringa oleifera leaves (EEMOL) (100 and 200 mg/kg)] orally for six weeks.  Biological evaluation including feed intake (FI), body weight gain % (BWG %) and feed efficiency ratio (FER) was carried. Sperm count, Sperm motility and sperm head abnormality were calculated. Serum (Testosterone, luteinizing (LH) and follicle stimulating (FSH) hormones were measured. Serum antioxidant enzymes (Super  Oxide Dismutase  (SOD), Glutathione Peroxidase (GPX), Catalase (CAT), level of  Malondialdehyde (MDA)  and  nitric oxide (No)  were estimated.  Also histopathological changes for testis, were examined. The obtained results concluded that using  EEPGL and EEMOL  improved   FI, BWG % and FER, sperm count, Sperm motility, sperm abnormality, serum hormones  and  antioxidant enzymes. The best results found by using high doses (200mg / kg) of EEPGL and EEMOL. According to the results, EEPGL and EEMOL could be used for improved sexual functions and protection from infertility,in male rats