This study was conducted to investigate the effect of some Marjoram extracts on Liver Cancer incident by Benzopyrene in Rats. Fourty-eight a dult male albino rats weigheing 170-190 g  were used in this study , and divided into two main groups . First group (6 rats) fed on basal diet as control (-) , second group was  induced liver cancer by Benzopyrene (100 mg/5 ml/kg body weight) dissolved in 0.9% NaCI solution containing 0.1% Tween 20 , Liver cancer rats groups and divided into 7 groups,  per each one of them were  liver cancer control positive . While the other six groups were divided into three groups fed a basal diet and give it Marjoram methanol extract 5 ml on every day in orel and other three groups fed on basel diet after replacing 0.5, 1  and 2% Marjoram powder  and feeding continued for 45 days . After the treatment ,  body weight gain (B.W.G and B.W.G%) , feed intake (FI) , feed efficiency ratio (FER) and blood samples were measured  and serum,(GOT),(GPT) , ALP, Albumin , Alpha-fetoprotein , Glutathione (GSH) and Malondialdehyde (MDA) levels were determined , and Histopathological structure of liver has been evaluated. The obtained results  revealed that feeding on  Marjoram extracts caused a significant (P ≤ 0.05) improvements in body weight gain (B.W.G%) , FER , liver functions , Alpha-fetoprotein , Glutathione (GSH) and Malondialdehyde (MDA)  as compared with control (+ve) group .
 
Histopathological investigations confirmed the biochemical changes in rats serum  . It could be concluded that marjoram was effective in protecting against liver cancer rats not only decreased the level of liver functions but also has beneficial effect on serum Alpha-fetoprotein , Glutathione (GSH) and Malondialdehyde (MDA) .Therefore , obtained data recommended this tested Marjoram extract and dry Marjoram by a moderate amount(0.75% and 2%) to be included in our daily drinks and dishes.