Wadi Zaghra granitoid intrusion is a part of the Neoproterozoic Pan-African basement cropping out in southern Sinai, Egypt. The intrusion comprises granodiorite, tonalite, monzogranites, syenogranite, and alkali feldspar granites with minor quartz-diorite. The present study includes geologic setting, field relationships, petrography, whole-rock geochemistry, mineral chemistry, and geothermo-barometry. Geochemically, Zaghra granitoid rocks are derived from peraluminous magma and exhibit a transitional calc-alkaline to alkaline magma type affinity of I type, as well as island arc setting belonging to the volcanic arc regime. Microprobe data of amphiboles are calcic-type and have the composition of actinolite, actinolite hornblende, magnesio-hornblende, and edenite. They are formed under low pressure. Biotites are Mg-rich and meroxene types. Plagioclase has a composition of albite and oligoclase fields with minor andesine. According to mineral chemistry, Wadi Zaghra granitoid rocks crystallized at an average pressure of about 1.4 Kb and a temperature range of 650 °C to an 700 °C.