Three granitic masses, namely Gabal Dellihimmi (140 km2), Gabal Abu Tiyur (30 km2) and Gabal Um Shaddad (17 km2) are located in the central Eastern Desert, intruded older metavolcanics and metasediments. They were studied petrographically, geochemically and rare earth elements were applied for petrogenetic modeling. Petrographically, Delihimmi granites are composed of orthoclase perthites, quartz, plagioclase and biotites whereas Abu Tiyur and Um Shaddad granites are composed of microcline perthites, quartz, plagioclase and minor biotites. Geochemically, Delihimmi, Um Shaddad and Abu Tiyur are classified as granites have characteristics of group Ɩ younger granites. Delihimmi granite has a normal calc-alkaline strongly peraluminous characters as well as characters of unfractionated M-,I- and S-types. ON the other hand, Abu Tiyur and Um Shaddad granites exhibit highly fractionated A-type characters. Spider diagrams reflect enrichment in LILE and HFSE except Zr and Yb depletion for Abu Tiyur and Um Shaddad granites while Delihimmi granite reflects enrichment in LILE and depletion in HFSE except Nb and Ce. The studied Delihimmi, Abu Tiyur and Um Shaddad granites were emplaced in a post orogenic tectonic environment. Rare earth elements normalized patterns for the studied granites reflect a fractionated enriched LREE and depleted HREE patterns with small to moderate negative Eu anomaly. Using REE petrogenetic modeling Delihimmi granite can be produced from 40% non-modal partial melting for the bulk continental source materials followed by 35% crystal fractionation but the Abu Tiyur (type 1) and Um Shaddad granites can be produced from 30% non-modal partial melting for the upper continental source materials followed by 40% crystal fractionation. On the other hand, Abu Tiyur granite (type 2) can be produced from granitic source materials by 50% partial melting followed by 60% crystal fractionation.