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275432

The Effects of Hyphaena thebaica and Lactobacillus in Dextran Sodium Sulphate-Induced Ulcerative Colitis in Rats

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Last updated: 23 Jan 2023

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Pharmaceutical Sciences

Abstract

Ulcerative colitis (UC) can cause a variety of complications, ranging from colon damage to colorectal cancer. The cause of UC, as well as successful treatment options, remain a mystery. The mechanisms behind the coloprotective benefits of Hyphaena thebaica (H. thebaica) and Lactobacillus, as well as their combined therapy on dextran sodium sulphate (DSS)-induced colitis in rats, are the subject of this study. The experimental panel included seven groups of rats; normal control, negative plus H. thebaica, negative plus Lactobacillus, UC diseased rats, H. thebaica treated, Lactobacillus treated, and combination of H. thebaica and Lactobacillus treated. Clinical evaluation of UC and both macroscopic and microscopic examination scoring was also done. Colonic oxidants/antioxidant stress biomarkers; malondialdehyde (MDA), glutathione (GSH), catalase, myeloperoxidase activity, and superoxide dismutase (SOD) activity were assessed. Colon Nrf2, HO-1 contents, TNF-α as well as caspase and Bax proteins was evaluated. H. thebaica in conjunction with Lactobacillus, greatly reduced dextran sodium sulphate-induced colon injury (DSS). In addition, the tested drugs dramatically decreased DSS-induced oxidative, inflammatory, and apoptotic activities.

DOI

10.21608/dusj.2022.275432

Keywords

ulcerative colitis, Hyphaena thebaica, lactobacillus, Heme Oxygenase-1 (HO-1), Tumor necrosis factor(TNF-α)

Authors

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Ahmed

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shata

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First Name

Ahmed

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Shaaban

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First Name

Hadeer

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Abou-Hany

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First Name

Sameh

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Saber

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Reham

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Goda

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Yasser

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Hassan

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Amira

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Mousa

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Bushra

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Etman

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Rania

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Shawkey

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Sara

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Nasr

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First Name

Salma

Last Name

Abdelraouf

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First Name

Salma

Last Name

Saraya

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First Name

Salma

Last Name

Negm

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Samaa

Last Name

Shoman

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Shrouk

Last Name

Kamal

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Mennatallah

Last Name

Warda

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First Name

Menna

Last Name

Attia

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First Name

Ahmed

Last Name

El-Baz

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Volume

5

Article Issue

2

Related Issue

38321

Issue Date

2022-12-01

Receive Date

2022-12-21

Publish Date

2022-12-01

Page Start

201

Page End

213

Print ISSN

2636-3046

Online ISSN

2636-3054

Link

https://dusj.journals.ekb.eg/article_275432.html

Detail API

https://dusj.journals.ekb.eg/service?article_code=275432

Order

275,432

Type

Original research papers

Type Code

1,769

Publication Type

Journal

Publication Title

Delta University Scientific Journal

Publication Link

https://dusj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

23 Jan 2023