Antihistaminic drugs are a group of therapeutic agents representing one of the most-widely prescribed medications for treating different diseases. They are often used to relieve symptoms of allergies, such as hay fever, conjunctivitis, and reactions to insect bites or stings. A comprehensive review with more than two hundred references reported on the analysis of selected antihistamines is explored. The selected drugs belong to different generations of antihistaminic drugs. These drugs include rupatadine, montelukast, desloratadine and fexofenadine.. The literature review covers most methods described for determining these drugs in bulk powder, pharmaceutical dosage forms, animal tissues and biological fluids. Different analytical techniques include UV and Visible spectrophotometry, spectrofluorometry, thin-layer liquid chromatography, high-pressure liquid chromatography, ultra-performance liquid chromatography, gas chromatography, capillary electrophoresis, and electrochemical methods.