Cancer remains one of the biggest global health issues today due to the disease's complexity and mutability. Moreover, despite the major advances in understanding its etiology and pathogenesis to improve prevention and treatment methods, the disease remains a major cause of natural death worldwide. Regardless of the cause or genotype of cancer, the malignancy phenotype at the cellular level results in observable physicochemical modifications. In this review, we will get focus on ten hallmarks of cancer acquired by most and perhaps all types of human malignancies, as a successful approach to combat cancer along with enhancing cancer prevention and revealing potential limitations in recent therapeutic interventions.