Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Although both men and women may become infected, UTIs are traditionally thought of as a disease of women, among whom 50% will be affected across their life span. Approximately 25% of women presenting with a first episode of bacterial cystitis go on to suffer recurrent UTI within 6 months, some having 6 or more infections in the year following the initial episode. IgA is the most abundant antibody isotype in the body, comprising almost 70 % of the body's total immunoglobulins. The majority of IgA is found in the various mucous secretions, including saliva, milk, colostrum, tears, and secretions from the respiratory tract, genitourinary tract, and prostate. Several studies have manifested that every change in sIgA levels may be associated with UTI. Finding rapid techniques to diagnose the patients with UTI is so important. In this case control study, we investigated secretory IgA as an early marker of urinary tract infection.