Kidney fibrosis is the common final pathway of virtually all progressive injury to the kidney and a promising therapeutic target in chronic kidney disease (CKD). Curcumin has renal protective properties against kidney fibrosis. The exact mechanism of such protection is not clear. Therefore, this study was conducted to examine the molecular levels of the protective effect of curcumin on cisplatin induced fibrosis in rats. We investigated the effects of curcumin in kidney fibrosis which was induced in male Sprague Dawley rats using cisplatin (4.5 mg/ kg in 2 consecutive days). Curcumin was administered by oral tubes 200 mg/kg daily for 21 days. Serum creatinine, creatinine clearance, urea nitrogen and oxidative stress markers [glutathione (GSH), lipid peroxide (Malondialdehyde)] assessments of these parameters were carried out to indicate the effect of curcumin in kidney fibrosis. Serum analysis revealed an alteration in parameters of kidney. A decrease in the antioxidant activity of kidney was recorded in cisplatin group while curcumin administration restored it. The results clarified the strong protective effect of curcumin on cisplatin induced kidney fibrosis in rats.