Pulicaria crispa, family Compositae is an annual herb, locally known as gethgath. The plant was reported to be used in Saudi Arabia on bruises, skin infections and gastrointestinal disturbances due to its essential oil content. It has been used from ancient times in the treatment of sinusitis and respiratory tract infections in the traditional medicine system in southern Iran. Many studies have been conducted on P. crispa essential oil in many countries in the middle east; the essential oil of P. crispa was found to be characterized by changes in the chemotype due to various factors including for example: the part of the plant used, stage of plant development, genetic factors, the environmental conditions, the harvest period and the nature of the soil. The oil showed antibacterial, sedative, antioxidant activity and cytotoxic activity. Moreover, the oil was reported to possess a good anticancer efficacy against human colorectal adenocarcinoma (Caco-2) and a slightly lower anticancer efficacy against hepatocellular cancer cell line (HepG-2).