Aim: The aim of this study was to evaluate the demographic characteristics, clinical features of uveitis of adult patients with Vogt-Koyanagi-Harada (VKH) disease uveitis in Mansoura Ophthalmic Center (MOC).
Methods: This was a descriptive cross sectional prospective study conducted on adult patients attending uveitis outpatient clinic of MOC. Entire cases were exposed to full history taking, ophthalmic history, ocular examination which included assessment of visual acuity, slit lamp examination, in addition, optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) were performed for selected cases.
Results: from 254 uveitic patients attending uveitis outpatient clinic, 41 VKH cases (81) eyes were examined. Mean age was 33.88 ± 9.3. Male to female (M/F) ratio was 29.3/70.7. The mean BCVA among the studied cases was 0.839±0.74 LogMar in which most of cases had severe vision loss (≤6/60) (41.9%) at presentation and most of the causes of vision loss were reversible. Among causes of vision loss, macular oedema represented the commonest cause 43.2% followed by neurosensory detachment 28.4% that was documented by OCT and FFA. All of cases received systemic prednisolone as initial treatment.
Conclusions: VKH-related uveitis is more common in the female gender in Egypt. VKH is a common cause of bilateral vision loss with a favourable visual outcome if intensive therapy is started early. Aggressive early management of cases of unilateral VKH prevents recurrence in the other eye.