Background: Mesotherapy involves the introduction of   various therapeutic agents in microscopic quantity to the skin for various  therapeutic applications. Phosphatidylcholine (PPC) increases the permeability of the adipocyte membrane and subsequent fat mobilization. Caffeine has an effect on adipocyte lipolysis via the inhibition of phosphoesterase, provoking an increase in adenosine mono phosphate (AMP), slow down lipogenesis (uptake of glucose and free fatty acids to synthesize triglycerides) and stimulate lipolysis. Our aim was to compare the efficacy, safety, and tolerability of phosphtidylcholine, caffeine and mesotherapeutic cocktail (Phosphatidylcholine, Organic silicium, L-Carnitine, Hyaluronic Acid, Sodium Pyruvate, Caffeine, Artichoke Extract, DMAE) in treatment of  abdominal obesity. Patients and Methods: Low caloric diet, exercise and mesotherapeutic injection for abdominal subcutaneous fat: Phosphatidylcholine/Deoxycolate (PPC/DC) for group I, caffeine for group II, lipolytic cocktail  for group III  weekly for six weeks. Results: All groups showed statistically significant reduction regarding anthropometric measurements, ultrasonographic evaluation and lipid profile after treatment being highest in group III followed by group I followed by group II . Minimal side effects have been occurred except PPC group showed 50% local allergy.  Conclusion: Mesotherapy is an effective method for adipolysis. Lipolysis cocktail allows the highest effect and the most safe drug for lipolysis.