Background: To evaluate in-hospital and six-month death rates among patients hospitalised for acute coronary syndrome, the Global Registry of Acute Coronary Syndrome (GRACE) risk score is employed (ACS). Methods: These findings show that the GRACE score is accurate in a contemporary cohort of 200 patients who were diagnosed with an acute coronary syndrome (ACS) and received either invasive or conservative treatment between January and August 2021 at the National Heart Institute or the Coronary Care Unit of the Cardiology Department of Benha University. By analysing the Hosmer–Lemeshow test's calibration and discriminatory power, the GRACE risk score was tested for its relevance in predicting benefit from invasive approach in patients with acute coronary syndromes. More than half of the 200 patients in this research were hospitalised for ST-elevation myocardial infarction (STEMI), whereas less than a third were admitted for non-STEMI myocardial infarction (MII). A total of 120 patients chose an intrusive technique, whereas only 80 chose a medicinal strategy. 33 of the 80 patients in the conservative group (A) had issues in the hospital, whereas 37 of the 120 patients in the invasive group (B) did the same. PATIENT HAS DEVELOPED A HOSPITAL COMPLICATED. For group A, the GRACE risk score had an AUC of 0.76338 (95 percent CI: 0.65518-0.85127) and for group B, it was 0.63986 (95 percent CI: 0.54719-0.72545). This indicates that the GRACE risk score is sufficiently discriminatory. The GRACE score was shown to be valid in predicting the benefit of an invasive method in patients with an acute coronary syndrome, and it was suggested that it be utilised on a regular basis