Introduction: We provide a case on care of large facial pores and seborrhea in 20-years old female with history of acne vulgaris and sun exposure (outdoor employment), non- smoker, no pregnancy or breastfeeding. presentation of case: Our patient appeared with broad facial pores and seborrhea, with history of acne vulgaris. Discussion: Calvani et al.reported correcting, in a session, laxity of the chinrest region and skin folds of the neck. However, in our selective case we used mesobotox topically with dermapen in treatment of wide facial pores based on the fact that calvani et al. mentioned in their study that the microtrauma induces the production of growth factors by multiplication of fibroblasts and the synthesis of collagen and elastin. Therefore, the approach given has this dual action and this technique was not employed previously in any research. Conclusion: Topical microbotox with microneedling demonstrated to have a reduction in facial pores and seborrhea after 1 month of treatment although this effect was transient and gone entirely at the 4 month follow up appointment