Complications that might arise from diabetes include kidney illness; neuropathy; retinopathy; and musculoskeletal (MSK) symptoms. MSK symptoms in people with DM might have a negative influence on their quality of life. Adhesive capsulitis, shoulder hand syndrome (SHS), diabetic hand syndrome (DHS), DISH, Dupuytren's contracture (DC), and neuroarthropathy are a few of the symptoms that might appear. Musculoskeletal imaging is becoming more and more common with the use of ultrasound, a very effective imaging modality. Patients with diabetes mellitus (DM) were studied utilising musculoskeletal ultrasound (MSUS) imaging in order to examine alterations in certain tendons, in both the upper and lower limbs, as well as their clinical condition, illness duration, glycemic management, and other laboratory data. Methods: Forty diabetic individuals who met the American Diabetes Association's definition of diabetes mellitus (DM) were studied in this research (Group I). Attendants of the Endocrinology unit of Benha University Hospitals' Internal Medicine department were invited to participate in the study. Group II: twenty-five seemingly healthy participants were chosen from hospital staff and relatives of other patients to serve as a control group. Conclusions: In this investigation, tendons were found to be prominent on one side in both the control and non-complaining groups. Tenderness in the biceps tendon was found in three healthy controls and 18 cases, whereas discomfort in the supraspinatus tendons was found in three healthy controls and six diabetes patients who underwent palpation testing. DM patients' Subscapularis tendons were found to be 10% painful, whereas Achilles tendons were found to be 25% tender. Twelve biceps tendons, eight supraspinatus tendons, and eight subscapularis tendons in DM patients had statistically negligible differences from healthy controls in terms of tendon degradation. Tendon thickness differences between DM patients and healthy controls were found to be statistically significant. There was evidence of effusion in four out of the eight biceps tendons evaluated, despite the fact that none of the healthy controls exhibited any signs of bicipital tendinitis. Diabetes patients had higher tendon calcifications in their biceps, supraspinatus, and subscapularis than healthy controls, although the differences were not statistically significant. Over 5 percent of the supraspinatus tendons had partial tendon tears, but no partial tendon tears were found in any of the Subscapularis tendons, and no full thickness tears were found in any of the tendons we investigated. Tenderness in the Achilles tendon was seen more often in people with diabetes than in healthy controls, although the difference was statistically insignificant. According to MSUS, the investigated patients had greater Achilles tendon degeneration, calcium deposits, and a retrocalcaneal bursa than the healthy controls did, although the differences were statistically insignificant. Even though there was a statistically significant difference in the thickness of the tendon between the two groups investigated, the DM patients had the thickest tendon. Tendon thickness was shown to have a strong connection with illness duration and HbA1C. Biceps tendon thickness was shown to be significantly correlated with patient age. Our findings demonstrate that DM may lead to degenerative alterations in the investigated tendons. Using ultrasonography, a nonradioactive diagnostic technology that aids in the diagnosis of disease and degeneration, doctors may examine patient's right at their bedsides