Background: Amblyopia is reduced vision that is caused by disruption of the normal development of vision during childhood. Aim and objectives: the main aim of this study was to detect macular vascular changes in amblyopic eye by optical coherence tomographic angiography. Subjects and methods: This cross-sectional comparative observational study was conducted on 59 patients with amblyopia. this study enrolled patients from May 1,2021, through December 1,2021. All participants in this study signed their written consent to participate.This study was approved by ethical committee on May 1,2021. Results: The foveal and parafoveal macular vessel density was lower in amblyopic eye than control eye . Severe OCTA changes were found to be significantly related to patients with high error of refraction and degree of amblyopia. As regarding UCVA and BCVA, it was found that they were both significantly lower among patients with severe changes compared to those with mild and moderate changes (0.04, 0.10 versus 0.25, 0.10, 0.25 and 0.25 respectively). Conclusion: Young  patients with amblyopia have reduced superficial and deep retinal capillary density on OCTA. These vascular changes may be associated with decreased visual acuity. Our findings indicate a possible association between retinal microcirculation and amblyopia. The clinical relevance of this finding remains to be determined