Isolated Tibial shaft fractures with intact fibula are common injury accounting for about 20-22% of tibial diaphyseal fracture with  high rate of, delayed union, and non-union. To assess the efficacy of primary partial fibulectomy in treatment of isolated tibial shaft fractureThis study was conducted on 40 patients who had isolated tibial shaft fracture with intact fibula in adults divided in to 2 groups.Group I (20 cases): was treated by combind primary partial fibulectomy and interlocking nail.Group II (20 cases): was treated by interlocking nail without primary partial fibulectomy between May 2018 and Septemper 2021. in Benha university hospitals. Results in this study were assessed according to the criteria given by the Association for the Study and Application of the Methods of Ilizarov (ASAMI score) All Fractures in group I  united at an average duration of 17.6 weeks while in group II  the average duration of union was 23.5 weeks. There is astatistically high significant difference in the union time ( P- value = 0.0010**).Non union was observred in 2 cases in group II, one case with hypertrophic non union managed by partial fibulectomy and one case with atrophic non union managed with partial fibulectomy and bone graft. Primary Partial fibulectomy has proved to be a reliable procedure to successfully manage acute tibial shaft fracture with intact fibula and   overcome problems encountered in bone healing as delayed union and non union