Background: Assessment of LV functions with M-mode or 2-dimensional echocardiography can be performed in the parasternal long- and short-axis views by placing the calipers perpendicular to the ventricular long axis. Current speckle-tracking echocardiography (STE) techniques require the acquisition of standard parasternal and apical images. The aim of this work was to detect the efficacy of STE to evaluate subclinical LV dysfunction in patients with sepsis. Methods: This case control study was carried out on 80 subjects. Subjects were divided into two equal group: group (I): diagnosed with sepsis or septic shock and group (II): normal individuals. Then group I was subdivided into two subgroups: subgroup I: 25 patients with septic shock and subgroup II:15 patients with sepsis. All patients were subjected to laboratory investigations (CRP, white blood cells, d-dimer, serum ferritin, platelets, bilirubin and creatinine), ECG, Echocardiography and STE.Results: PASP, LVEDV and LVESV were insignificantly different between septic shock and sepsis groups. A4C, A3C, A2C and GLS were significantly higher in septic shock group compared to sepsis and normal groups (P value < 0.05).Conclusions: Speckle-tracking echocardiography can detect early subclinical LV systolic dysfunction via the LV GLS, compared with conventional echocardiographic parameters in patients with septic shock