Background: Genital warts are a kind of sexually transmitted diseases caused by certain types of human papillomavirus (HPV). The main clinical manifestation of genital warts is benign hyperplasia of the skin and mucous membrane in the genitalia, anus and perineum. Genital warts not only affect physiological function but also cause psychological stress. HPV is the most common sexually transmitted infection globally, and most people are infected at some point in their lives. One major benefit of the H2O2 gel does not destroy healthy, uninfected tissues nor results in significant systemic side effects, local side effects such as irritation, necrosis of tissue surrounding the wart, allergic rashes, scarring, disfigurement or discomfort to the human treated there with. The aim of the present study was to assess the evaluation of different concentrations of hydrogen peroxide gel (10% and 20%) as a potential new therapeutic option of genital warts.Methods: This study is an interventional study which included 30 patients suffering from genital warts. All patients were selected from the outpatient clinic of dermatology and andrology department at Benha university hospitals. Results: There was no Statistical difference regarding age and gender between study groups. There was no statistical difference regarding disease duration. There was no statistical difference regarding Numbers and size of warts before treatment. Number of lesions decreased significantly in the three studied groups after 6 weeks of treatment. size of lesions decreased significantly in the three studied groups after 6 weeks of treatment. There is statistical difference regarding partial Treatment responses of study groups after 2 and 6 weeks. There is significant statistical difference regarding complete Treatment responses of study groups after 2 and 6 weeks. Size and number of lesions had negative impact on treatment responses. There was no statistical difference regarding Side effects recorded. Conclusion: Hydrogen Peroxide Gel (10% and 20%) was effective as treatment for genital warts with more efficacy of Hydrogen Peroxide Gel 20% than 10% with no severe side effects and more response rate. A once-daily application of topical H2O2 gel at bed time for 6 weeks can be considered a an effective, safe, cheap, and easy to use new topical treatment for genital warts with low recurrence rates.