Background: High Alert Medications (HAMs) management is a vital part of nurses' responsibilities in their everyday practice. So, it is important to provide basic education and continued program for nurses to improve their competences about HAMs. The study aimed to evaluate effect of an educational program for nurses about HAMs on their competence. Design: Quasi experimental design was utilized to conduct this study. Setting: The study was conducted at Emergency Department at Benha University Hospital. Subjects: Consisted of all nurses (34) who are working at the above-mentioned setting. Three tools were used for data collection: HAMs knowledge questionnaire, Observational checklist for nurses' performance and Nurse's competence scale. Results: The majority (91.2%, 85.3%) of the studied nurse had satisfactory knowledge regarding HAMs at immediate post and follow up, respectively, most of them (85.3%, 79.4%) had high performance regarding HAMs at immediate post and follow up, respectively while the majority (88.2%, 85.3%) had high competence level regarding HAMs at immediate post and follow up, respectively. Conclusion: the current study concluded that the educational program was successful and lead to improvement in nurses' knowledge, performance, and competence regarding HAMs at immediate post program and follow up program (after 3 months). Also, there was highly statistically significant correlation between nurses' knowledge, performance and competence related to HAMs at pre, immediate post and follow up phases of program. Recommendations:Establishing job orientation for newly graduates' nurses regarding HAMs. Also, conducting training programs and workshops periodically for nurses to enhance their competence regarding HAMs.