Background: Psoriasis is a chronic inflammatory skin disease, affecting 1.5–3% of the world population. The
pathogenesis of psoriasis is complex and depends on many factors, including genetic, neurogenic, hormonal and
autoimmune. The present study aims to evaluate serum C1q/TNF‐related protein isoform 15 (CTRP15) level in psoriatic
patients. This case control study included 80 subjects divided into 2 groups Group A included 50 patients suffering from
generalized plaque psoriasis and Group B included 30 apparently healthy individuals of matched age and sex were chosen
as a control group. All subjects were selected from the Outpatient Clinic of Dermatology and Andrology at Benha
University Hospital from October 2020 to April 2021. Patients were told to stop using topical therapy for 2 weeks or
systemic therapy for 4 weeks before the study. Psoriasis was diagnosed clinically and confirmed by dermoscopic
examination and curttage test. All the patients were subjected to full history taking, complete clinical examination, and
laboratory investigations as Fasting blood glucose, Lipid profile (TC,TG,HDL and LDL). Results & Conclusion: The
present study showed that the mean age of psoriasis group was 46.3 years, they were 32 males (64%) and 18 females
(36%). In addition to 30 healthy control group of matched age and gender (p>0.05 for each). no significant differences were
found between studied groups regarding blood pressure. The present work found that patients had significantly higher BMI
and WC when compared to control group and positive family history of psoriasis