Background: The marker is the major component, is a specific marker of caveolae, and is generally distributed in smooth muscle cells, endothelial cells, skeletal myoblasts, fibroblasts and adipocytes. It modulates a wide range of cellular events such as proliferation, lipid metabolism, cellular tracking and signal transduction. Matrix metalloproteinase-1 (MMP-1) protein levels were negative or low in dysplastic warts. Serum and tissue level of marker enhances cell surface plasminogen activation and regulation of MMP-1.  Objectives: The aim of this study was to evaluate the serum and tissue level of marker in patients with common warts and compare their levels with healthy controls. Method: The present study included 30 patients with common warts. In addition to 10 age and sex matched apparently healthy controls were included in the study. Any subject was presented with any of the following conditions was excluded from the study; patient less than 15 years old and above 35 years, patient taking topical medication, patient with hypertension or diabetes and patient with any systemic diseases. All subjects were evaluated for serum and tissue level of marker by enzyme-linked immunosorbent assay (ELISA). Results: No significant differences were found between studied groups regarding occupations. Hand was the most affected site (56.7%), followed by leg and thigh. Most of cases (76.7%) were affected by multiple lesions. Mean size was 6.2 mm.  Conclusion: From the results of present study, it is concluded that there were no significant differences were found between studied groups regarding occupations. Hand was the most affected site (56.7%), followed by leg and thigh. Most of cases were affected by multiple lesions. Mean size was 6.2 mm.