Purpose: evaluate of preoperative charcoal localization of primary non palpable lesions, Encourage the policy of screening & early detection among asymptomatic women especially who are at risk and increase the rate of breast conservative surgery (BCS) in management of breast cancer. Methods: The present prospective study included 30 patients with nonpalpable breast mass. A mean Age of 50.83 ± 15.72years. 30 patients underwent lumpectomy modified radical mastectomy (MRM) and BCS. From Nov 2019 to May 2022. Results: included 30 patients their age ranged from 21 to 77 years with mean age 50.83 years, 36.7% of the studied patients had positive family history, 50% of the studied patients have no complain, 23.3% of the studied patients complained of breast lump, 13.3% had breast pain, where bleeding per nipple, nipple discharge, nipple retraction and complained of nipple ulceration had 3.3% to each, Regarding site of lesion, 40%, 20%, 16.7%, 13.3%, 6.6%, 3.3% had lesions in upper outer quadrant, areola, lower outer quadrant, and upper inner quadrant, central, lower inner quadrant respectively, 50%, and 43.3%%, had right-sided and left sided lesions respectively. Bilateral lesion was present in two patients (6.7%), 53.3% of patients had benign lesions while fourteen patients (46.7%) had malignant lesions, the patient underwent lumpectomy 54%, BCS 10 patients 33% while 4 patients (13%) had MRM, 56.7% patients had no inflammatory response, 13 patient had acute inflammatory response. Of them, 30% had mild response while 13.3% had moderate inflammation. No of them had severe inflammatory response with abscess formation. Only one specimen of them showed severe inflammatory response, Conclusion: US Guided Injection of Charcoal Suspension for non-palpable breast lesions is a very simple, safe and accurate method. After localization by this method.