Despite recent advances in detection and treatment approaches, sepsis remains a significant cause of mortality globally. According to the Third International Agreement for Sepsis (Septic-3) consensus, the term "septic shock" is a subset of the more general term "sepsis" since it includes hypotension or an elevated lactate level despite attempts to revive the patient. Sepsis is caused by a variety of organisms, including Gram-positive and Gram-negative bacteria that produce toxins, an immune-compromised host, and maybe a genetic predisposition. When sepsis strikes, the body's response is immune-inflammatory, accompanied by the release of pro-inflammatory cytokines, which in turn triggers a neuro-endocrine cascade that leads to metabolic dysfunction and organ dysfunction. Cellular abnormalities such as mitochondrial damage and cytopathic hypoxia are also present. Taking 200 mg thiamine for a week post-ICU with high-dose short-term vitamin C and a 5-day Vitamin D supplementation for deficient individuals appears to be the most sensible course of action. It is a series of coordinated efforts used to establish the best kind, dosage and duration of nutrition treatment to achieve the highest therapeutic result, prevent side effects, and save costs. the following: Nutritional Stewardship and pharmaconutrition play a critical role in the treatment of sepsis, as well as the implementation of Nutritional Stewardship in the clinical context