Background: All medical illnesses that affect the heart, blood, or blood vessels are known as cardiovascular diseases (CVDs). If the atherosclerotic plaque develops as a reaction to physical or metabolic harm, a stroke may occur, and this can be life-altering. It is now common practise to use duplex ultrasonography (DUS) to detect carotid disease. An overall sensitivity of 97% and a specificity of 100% were established for CTA in detecting the degree of carotid obstruction. The purpose of this study is to compare the findings of carotid duplex examinations of the extracranial carotid circulation with those of CT angiography. First assault of transient and non-transient cerebral insults in patients brought to the ICU. 40 ICU patients with a transitory or persistent neurological disability owing to carotid atherosclerosis were studied in a prospective case-serious research. Analysis of each parameter was done using a statistical tool for social science data that was used to revise, code, tabulate, and introduce the data to a PC. Results There was an overall concordance of 77.5 percent (31/40) between CDUS and CTA, with CDUS underestimating the degree of stenosis in 7/40 (17.5 percent) and CTA overestimating the degree of stenosis in 2/40 (5 percent). Other criteria were not linked to concordance or disconcordance. The stenosis grades of the duplex US and CT angiograms were identical, with 100% sensitivity, 100% specificity, 100% PPV, 100% NPV, and 100% accuracy. As a result, DCUS and CTA were shown to have good agreement, whereas CDUS remains the first-line non-invasive imaging approach for the evaluation of ICA stenosis.