Background; Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that includes numerous neurological regions. In addition to lower urinary tract symptoms (LUTS), sexual dysfunction (SD), and psychopathological consequences, MS occasionally substantially impacts the quality of life (QoL) (QoL), Aim and goals; to analyse the incidence of lower urinary tract symptoms and sexual dysfunction in patients with multiple sclerosis and to study the association between the degree of neurological impairment in multiple sclerosis and lower urinary tract symptoms and sexual dysfunction, Subjects and methodologies; This is A cross-sectional research, was done at the Neurology outpatient clinic of Benha University Hospital, Result: There was strong statistically significant link between sexual dysfunction and both ICSmSF and quality of life and statistically significant relation between sexual dysfunction and both ICSV and ICSI, Conclusion; LUTS and SD are significantly frequent in males with MS, and both have a detrimental influence on QOL. The degree of neurological impairment corresponds with the severity of LUTS and SD. Given the significant incidence of LUTS and SD in men with MS, a more attentive emphasis on these areas is needed to assist patients achieve better management of LUTS and enhance their sexual health with consequent improvements to their QOL