Public health officials and obstetricians alike want to avoid premature delivery wherever possible. Pregnant women at high risk of preterm labour may have been the most effective method of preventing preterm labour. Pharmacological therapy with a variety of drugs has been the primary method for managing acute preterm labour. The primary goal of this research is to assess the effectiveness, success rate, and outcomes for both the mother and the baby with progesterone and nifedipine given to women at risk of preterm delivery as tocolytic medications. Benha University Hospital and Belbeis Central Hospital chose patients from the inpatient clinics of the Obstetrics & Gynaecology Department. For four doses of intramuscular dexamethasone, all patients received injections of 6mg intramuscularly every 12 hours. Two groups of 60 participants each were included in the prospective comparative interventional trial, with 10 patients being lost to follow-up. nifedipine 20 mg orally every 12 hours from diagnosis until 34 weeks was given to thirty pregnant women with imminent preterm delivery in the form of a 20mg tablet. Group II: Thirty patients received 400mg micronized progesterone vaginally at admission time and once at bedtime for the first 48 hours of treatment. 30 women got nifedipine with gestational age (median 30 weeks), 30 received progesterone with gestational age (median 31 weeks), and the patients who were originally recruited had successful acute tocolysis with nifedipine. We found that nifedipine was more often associated with side effects than progesterone in our study. No one in our study had to discontinue taking their medication due to adverse effects or intolerance. However, Females in the nifedipine group reported feeling drowsy 16.7 percent of the time, compared to none in the progesterone group. Researchers did not find any evidence of nausea (10%), sadness (3.33%), or Git symptoms (3.33%) among the niedipine side effects studied.