Background: Prognostic modeling in hepatocellular carcinoma patients has a high complexity and should consider 4 tightly related aspects; tumor stage, degree of liver function impairment, patient's general condition and treatment efficacy Objectives: The aim of this study was to determine the different prognostic factors of liver resection for large hepatocellular carcinoma in cirrhotic patients. Patients and Methods: In this retrospective cohort study, 65 cirrhotic patients had liver resection for large hepatocellular carcinoma in the period from January 2015 until December 2019, at National liver institute, Menoufia University and Benha Faculty of Medicine, Benha University. The recurrence and survival data along with patients' data were recorded to identify potential prognostic factors in those patients.  Results: Recurrence had occurred in 33 patients (52.38%) while mortality occurred in 15 patients (23.1%). Findings on upper endoscope, the site and size of the tumors, the preoperative AJCC stages and pathological grade of tumors affected the recurrence significantly (p 0.015, 0.001, <0.001, 0.035 and <0.001, respectively) while the preoperative serum albumin, the presence of vascular invasion and Barcelona class affected mortality significantly (p 0.002, 0.002 and 0.024, respectively). By multivariate analysis, the mean size of HCC and the pathological grade of tumor were the most significant factors that affected the recurrence while the presence of portal vein invasion by the tumor was the most significant factor that affected the survival.  Conclusion: Findings on upper endoscope, the site and size of the tumors, the preoperative AJCC stages and pathological grade of tumors were independently associated with recurrence while preoperative serum albumin, the presence of vascular invasion and Barcelona class were associated with survival. On multivariate analysis, the mean size of HCC and the pathological grade were the most significant factors affected the recurrence while the presence of vascular invasion was the most significant factors that affect the survival.