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Serum level of Alarin in Patients with Androgenetic Alopecia

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Last updated: 28 Dec 2024

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Abstract

Background: With androgenetic alopecia, hair follicle size decreases dramatically, which may be linked to the death of hair follicle stem cells or progenitor cells in the scalp. To far, scientists believe that AGA is caused by two things: a hereditary predisposition and androgens. In the last several decades, obesity and the metabolic syndrome have spread like wildfire across the globe, posing serious health and economic issues. According to some reports, Alarin is linked to increased caloric intake and weight gain. However, it's unclear if high levels of Alarin in the blood correlate with insulin resistance or the metabolic syndrome. Recent research shows a connection between AGA and cardiovascular disease (CVD), diabetes mellitus and hypertension dating back to the early 1990s (HT). The study's goal was to find out whether there was a link between high levels of serum alarin and androgenic alopecia, as well as obesity and the metabolic syndrome. Methods: The research was carried out at the outpatient clinic of the Benha University Hospitals' Dermatology and Andrology Department in the year 2020. There were 80 people in all, divided into two groups: First, there were 50 patients with androgenic alopecia (Hamilton–Norwood grades I–VII) and 30 age- and sex-matched controls in the first group. Results: In terms of AGA grades, grade 5 was the most common, followed by grades 4 and 2 each (20% each), and finally grade 3. (16 percent ). Grades 1 and 6 were the least common, with only 10% of students achieving them. Those with metabolic syndrome (median=6.38, min-max=0.99-80) had substantially higher levels of alarin (P=0.001) than those without (median=1.08, min-max=0.22-8.37); A significant positive correlation was found between the Alarin level and triglycerides (r = 0.723), cholesterol (r = 0.603), LDL (r = 0.333 & P-value = 0.015), VLDL (r = 0.466) and FBS (r = 0.596 & P-value = 0.001). Neither the alarin level nor HDL, age of illness start, length or systolic blood pressure showed any significant correlations AGA patients had substantially higher median Alarin levels than controls (0.95, IQR; 0.51–1.12) (5.58), IQR; (1.88–10.0), respectively). The P-value was below a threshold of 0.001. P-value was 0.001 because the Alarin level revealed a significant variation among AGA grades; the meidan was 1.05 in grade 1, 1.88 in grade 2, 2.15 in grade 3, 6.38 in grade 4, and 11.0 in lesson 5 and 20.5 in grade 6. Conclusion: Over 70% of adult males and 50% of adult females suffer from androgenetic alopecia (AGA), the most prevalent form of hair loss. This study's findings show that high levels of Alarin are linked to AGA, and that these levels rise as the severity of the illness increases. Additionally, Alarin levels were substantially greater in those with metabolic syndrome and were linked to a higher lipid profile in these patients. According to the results of the present research, another new discovery indicates that Alarin may be able to predict MS and AGA.

DOI

10.21608/bjas.2021.210895

Keywords

Alarin, androgenetic alopecia

Authors

First Name

A.M.

Last Name

Hamed

MiddleName

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Affiliation

Dermatology, Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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First Name

G.M

Last Name

.Abdel Khalik

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Affiliation

Dermatology, Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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First Name

M.G.

Last Name

Abdel Fatah

MiddleName

-

Affiliation

Dermatology, Venereology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Volume

6

Article Issue

6

Related Issue

29659

Issue Date

2021-12-01

Receive Date

2021-12-27

Publish Date

2021-12-01

Page Start

11

Page End

22

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_210895.html

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https://bjas.journals.ekb.eg/service?article_code=210895

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2

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Serum level of Alarin in Patients with Androgenetic Alopecia

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Article

Created At

23 Jan 2023